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  • MAb Technologies | Your source for quality monoclonal and polyclonal antibodies

Serotonin Transporter-human (ST51-2)

Serotonin Transporter-human  (ST51-2)
This mouse monoclonal antibody displays punctate staining along fibers in regional patterns consistent with 5-HT fibers. Neurons are detected in the Dorsal/Median Raphe Nucleus. A western blot of monkey tissue shows regional distribution consistent with published data. Prominent bands are detecte ...Read more
$275.00 each
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SERTThis mouse monoclonal antibody displays punctate staining along fibers in regional patterns consistent with 5-HT fibers. Neurons are detected in the Dorsal/Median Raphe Nucleus.

SERT blotA western blot of monkey tissue shows regional distribution consistent with published data. Prominent bands are detected at ~92kD and ~60kD.

Catalog #ST51-2

Size: 50 ul hybridoma media in glycerol.

Host: Mouse

Known Specificity: Human and non-human primate.

Recommended Dilutions:  IHC 1:5,000-10,000

                                 Western blotting  1:7,500-10,000

These working conditions are provided as a suggestion only. Each user should determine optimal conditions for his or her own experiment.

Source: This mouse monoclonal antibody was raised against a peptide from the N-terminus coupled to KLH by the addition of an N-terminal cysteine. Hybridoma media was obtained from cells grown in a bioreactor.

 

 

 

 

 

 

 

 

 

 

 

References

(All papers reference our antibody)

Blotting:

Kumar, V et al.--Novel Azido-Iodo Photoaffinity Ligands for the Human Serotonin Transporter Based on the Selective Serotonin Reuptake Inhibitor (S)-Citalopram. J. Med. Chem., 2015

Field, JR et al.--Transmembrane Domain 6 of the Human Serotonin Transporter Contributes to an Aqueously Accessible Binding Pocket for Serotonin and the Psychostimulant 3,4-Methylene Dioxymethamphetamine.  J Biol Chem, 2010.

Chamba et al.--Characterisation of the endogenous human peripheral serotonin transporter SLC6A4 reveals surface expression without N-glycosylation. J Neuroimmunol, 2008.

Iceta, R et al--Regulation of the human serotonin transporter mediated by long-term action of serotonin in Caco-2 cells. Acta Physiol (Oxf), 2007.

Brenner, B et al.--Plasma serotonin levels and the platelet serotonin transporter. J Neurochem, 2007.

Harish, CP et al.--Human serotonin transporter variants display altered sensitivity to protein kinase G and p38 mitogen-activated protein kinase. PNAS, 2005.

Guttman, M et al.--Regional distribution of serotonin transporter protein in postmortem human brain Is the cerebellum a SERT-free brain region?. Nucl Med Biol, 2005.

Smith, LJ et al.--Effects of ovarian steroids and raloxifene on proteins that synthesize, transport, and degrade serotonin in the raphe region of macaques.  Neuropsychopharmacology, 2004.

Henry, LK et al.--Serotonin and cocaine-sensitive inactivation of human serotonin transporters by methanethiosulfonates targeted to transmembrane domain 1. JBC, 2003.

Serafeim, A et al.--5-Hydroxytryptamine drives apoptosis in biopsylike Burkitt lymphoma cells: reversal by selective serotonin reuptake inhibitors. Blood Journal, 2002.

Ramsey, IS & DeFelice, LJ.--Serotonin transporter function and pharmacology are sensitive to expression level: evidence for an endogenous regulatory factor. JBC, 2002.

Bauman, AL et al.--Cocaine and antidepressant-sensitive biogenic amine transporters exist in regulated complexes with protein phosphatase 2A. J Neuroscience, 2000.

ICC/IHC:

Rajkowska, G et al.--Length of axons expressing the serotonin transporter in orbitofrontal cortex is lower with age in depression. Neuroscience, 2017.

Xu, Z et al.--Direct Conversion of Human Fibroblasts to Induced Serotonergic Neurons.  Molecular Psychiatry, 2015.

Zhu, CB, et al.--Colocalization and Regulated Physical Association of Presynaptic Serotonin Transporters with A3 Adenosine Receptors.  Molecular Pharmacology, 2011. 

Sidhu, A et al.--Partial regulation of serotonin transporter functions by γ-synuclein.  Neuroscience Letters, 2009.

Salli, U et al.--Serotonin neurons derived from rhesus monkey embryonic stem cells: similarities to CNS serotonin neurons. Exp Neurol, 2004.

Lu, NZ et al.--Ovarian steroid regulation of serotonin reuptake transporter (SERT) binding, distribution, and function in female macaques.  Nature, 2003.

Freedman, LJ & Maddox, MT--A comparison of anti-biotin and biotinylated anti-avidin double-bridge and biotinylated tyramide immunohistochemical amplification. J Neuroscience Methods, 2001.

Immunoprecipitation:

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